Registration Number
0226U001846,
(0125U001633)
, R & D reports
Title
New synthetic substances with antimicrobial properties for treating wounds
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Нові синтетичні речовини з антимікробною дією для обробки ран
Head
Kozak Mariia R., Кандидат біологічних наук
Registration Date
02-02-2026
Organization
Institute of Animal Biology of the National Academy of Agrarian Sciences of Ukraine
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To develop and investigate the effectiveness of a new drug with antimicrobial action created on the basis of a synthetic analogue of raw materials of plant origin for the treatment of wounds and wound surfaces
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Organosulfur compounds, analogues of natural biologically active substances of plant origin, have been
synthesized. The advantage of synthetic organosulfur compounds over natural analogues is resistance to
degradation and, accordingly, prolongated antimicrobial effect. Liquid forms of the synthesized compounds
were developed and their effect on the growth of microorganisms in vitro was studied. Compound ETC1
showed high antibacterial activity against E. coli, S. aureus, and C. albicans. Compound ETC2 also has high
antibacterial and antifungal activity, but weaker than ETC1. The minimum inhibitory concentrations of the
developed liquid forms of new synthetic substances (ETS1 and ETS2) were determined. The compound with
the most effective antimicrobial effect was selected. An experimental preparation based on S-ethyl-4-
aminobenzenethiosulfonate in a 50% dimexide solution was formed. New experimental drug provides
wound protection and scar-free healing in mice. The scientific novelty of the project is established
relationship of chemical structure and antimicrobial activity. This will help scientists to overcome the
resistance of microorganisms via creating effective methods of modification and synthesis of known and
new antimicrobial substances. Practical value of the proposed work lies in the possibility of developing new,
effective, safe and easy-to-use medicines for healing wounds and injuries of various etiologies.
Product Description
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Nataliia V. Kuzmina
Iryna M. Petrukh
Yurii V. Martyn
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2026-02-02
