Пошук академічних текстів

Інформація × Реєстраційний номер 2124U000943, Матеріали видань та локальних репозитаріїв Категорія Стаття Назва роботи Antioxidant, anti-inflammatory and epigenetic potential of curcumin in Alzheimer's disease Автор Abdul-Rahman T.Awuah W.A.Mikhailova T.Kalmanovich J.Mehta A.Ng J.C.Coghlan M.A.Zivcevska M.Tedeschi A.J.de Oliveira E.C.Kumar A.Cantu-Herrera E.Линдін Микола СергійовичСікора Катерина ОлексіївнаAlexiou A.Bilgrami A.L.Al-Ghamdi K.M.Perveen A.Papadakis M.Ashraf G.Md.Abdul-Rahman T.Awuah W.A.Mikhailova T.Kalmanovich J.Mehta A.Ng J.C.Coghlan M.A.Zivcevska M.Tedeschi A.J.de Oliveira E.C.Kumar A.Cantu-Herrera E.Lyndin Mykola SerhiiovychSikora Kateryna OleksiivnaAlexiou A.Bilgrami A.L.Al-Ghamdi K.M.Perveen A.Papadakis M.Ashraf G.Md. Дата публікації 01-01-2024 Постачальник інформації Сумський державний університет Першоджерело https://essuir.sumdu.edu.ua/handle/123456789/101859 Видання Wiley Опис Alzheimer's disease (AD) constitutes a multifactorial neurodegenerative pathology characterized by cognitive deterioration, personality alterations, and behavioral shifts. The ongoing brain impairment process poses significant challenges for therapeutic interventions due to activating multiple neurotoxic pathways. Current pharmacological interventions have shown limited efficacy and are associated with significant side effects. Approaches focusing on the early interference with disease pathways, before activation of broad neurotoxic processes, could be promising to slow down symptomatic progression of the disease. Curcumin—an integral component of traditional medicine in numerous cultures worldwide-has garnered interest as a promising AD treatment. Current research indicates that curcumin may exhibit therapeutic potential in neurodegenerative pathologies, attributed to its potent anti-inflammatory and antioxidant properties. Additionally, curcumin and its derivatives have demonstrated an ability to modulate cellular pathways via epigenetic mechanisms. This article aims to raise awareness of the neuroprotective properties of curcuminoids that could provide therapeutic benefits in AD. The paper provides a comprehensive overview of the neuroprotective efficacy of curcumin against signaling pathways that could be involved in AD and summarizes recent evidence of the biological efficiency of curcumins in vivo. Додано в НРАТ 2026-04-17 Закрити