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Інформація × Реєстраційний номер 2119U002528, Матеріали видань та локальних репозитаріїв Категорія Стаття Назва роботи Analysis of pulmonary hypertension patient survival after treatment in referral center (data of first Ukrainian register) Автор Radchenko G.Zhyvylo I.Sirenko Y. Дата публікації 03-12-2019 Постачальник інформації Національний медичний університет імені О. О. Богомольця Першоджерело http://ir.librarynmu.com/handle/123456789/498 Видання Pulmonary Circulation Опис The aims of the study were: (1) to evaluate the Ukrainian reality of survival in patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH); and (2) to determine predictors of death. A total of 281 patients were enrolled (52 [18.5%] with CTEPH, 229 [81.5%] with PAH). Long-term survival (Kaplan–Meier) and its predictors (Stepwise binary logistic regression and Cox’s proportional hazards analyses) were evaluated in adult patients with PH (diagnosed by right heart catheterization [RHC]) within a prospective registry at a single referral center in Kyiv, Ukraine. Follow-up period was up to 51 months. The Kaplan–Meier survival rate for the total cohort was 93.3%, 86.8%, and 81.5% at one, two, and three years, respectively. Survival was better in patients with congenital heart diseases (CHD) in comparison with idiopathic PAH (long rank P¼0.002), connective tissue diseases (CTD; long rank P¼0.001) and CTEPH (long rank P¼0.04). Univariate Cox’s predictors of death were: functional class IV (odds ratio [OR]¼4.94; 95% confidence interval [CI]¼2.12–11.48), presence of ascites (OR¼4.52; 95% CI¼2.21–9.24), PAH-CTD (OR¼3.07; 95% CI¼1.07–8.87), PAH-CHD (OR¼0.28; 95% CI¼0.11–0.68), HR on treatment>105 beats per min (OR¼7.85; 95% CI¼1.83–33.69), office systolic BP<100mmHg (OR¼2.78; 95% CI¼1.26–6.1), 6MWT on treatment<340m (OR¼3.47; 95% CI¼1.01–12.35), NT-proBNP>300pg/mL (OR¼4.98; 95% CI¼1.49–16.6), right atrium square>22cm2 (OR¼14.2; 95% CI¼1.92–104.89), right ventricular square in diastole (OR¼1.08; 95% CI¼1.03–1.14), right ventricular square in systole (OR¼1.08; 95% CI¼1.02–1.11), mean pressure in right atrium per each 1-mmHg increase (OR¼1.02; 95% CI¼1.02–1.19). In multivariate Cox regression analyses only presence of ascites, office systolic BP<100mmHg, CHD etiology of PH, and NT-proBNP>300pg/mL were associated with survival. Додано в НРАТ 2025-04-14 Закрити