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Registration Number

0120U102501, ( 0221U102653  ) R & D request

Title

Regulators of DNA processing systems based on nano-sized metaloorganic complexes of d-metals as potential therapeutic agents for treat various types of diseases

Head

Govorun Dmitro M., Доктор біологічних наук

Registration Date

14-05-2020

Organization

Institute of Molecular Biology and Genetics of NAS of Ukraine

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Synthesis of Pd, Pt complexes with a square-planar coordination unit (similar to cisplatin) and replacement of NH3 molecules by the 1-allyl-3-(2-hydroxyethyl)thiourea, N-allylmorpholine-4-carbothioamide and 1-allyl-3-tert-butylthiourea for binding to DNA and study of their cytotoxicity and genotoxicity using a plant test system - Allium сера with a comparison drug the substance cisplatin.

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2024-12-10