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Information × Registration Number 0120U105188, ( 0221U000216  ) R & D request Title Chemical-genetic approach to the study of the effects of ACE-2 inhibition as a pharmacological model of COVID19 side effects in the nervous, intestinal, cardiovascular and hemostasis systems. Head Riabukhin Serhii V., Доктор хімічних наук Registration Date 30-11-2020 Organization Taras Shevchenko National University of Kyiv popup.description1 Develop and test a pharmacological model to study the side effects of COVID-19 based on a chemical-genetic approach to disabling the catalytic activity of ACE2. Create a set of low molecular weight chemical probes for ACE2 inhibition based on different chemotypes, according to the "intended" approach. Create a profile for the developed chemical probes, which will include chemical properties, biological efficiency, biological selectivity and description of use. Join the global fight against the COVID-19 pandemic by disseminating information on the ACE2 chemical probes obtained to the world scientific community, in order to accelerate success in this fight and accelerate the development of new drugs against COVID-19. popup.nrat_date 2024-12-10 Close