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Information × Registration Number 0121U111736, ( 0222U003946  ) R & D request Title Chemical-genetic approach to the study of the effects of ACE-2 inhibition as a pharmacological model of COVID-19 side effects in the nervous, intestinal, cardiovascular and hemostasis systems Head Riabukhin Serhii V., Доктор хімічних наук Registration Date 22-06-2021 Organization Taras Shevchenko National University of Kyiv popup.description1 Develop and test a pharmacological model to study the side effects of COVID-19 based on a chemical-genetic approach to disabling ACE2 catalytic activity. Create a set of low molecular weight chemical probes (minimum 4 examples) for ACE2 inhibition based on different chemotypes, according to the "fit-for-purpose" approach. Create a profile for the developed chemical probes, which will include chemical properties, biological efficiency, biological selectivity and description of use. Join the global fight against the COVID-19 pandemic by disseminating information on obtained ACE2 inhibition chemical probes to the world scientific community, to accelerate success in this fight and to accelerate the development of new drugs against COVID-19. popup.nrat_date 2024-12-09 Close