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Information × Registration Number 0121U111840, ( 0222U000438  ) R & D request Title The chemical genetics approach to study the ACE-2 knockdown consequence as the pharmacological model of COVID19 side-effects in nervous, gut, hemostatic and cardiovascular systems Head Borysova Tatiana О., д.б.н. Registration Date 27-06-2021 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description1 Develop and test a pharmacological model to study the side effects of COVID-19 based on a chemical-genetic approach to disabling the catalytic activity of ACE2. Create a set of low molecular weight chemical probes for ACE2 inhibition based on different chemotypes, according to the "intended" approach. Create a profile for the developed chemical probes, which will include chemical properties, biological efficiency, biological selectivity and description of use. Join the global fight against the COVID-19 pandemic by disseminating information on the ACE2 chemical probes obtained to the world scientific community, in order to accelerate success in this fight and accelerate the development of new drugs against COVID-19. popup.nrat_date 2024-12-09 Close