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Information × Registration Number 0125U002583, R & D request Title A Prospective, Open-Label, Single-Center Observational Study on the Safety and Efficacy of Transarterial Chemoembolization and Systemic Therapy in Patients with Hepatocellular Carcinoma with Extrahepatic Spread and Preserved Liver Function Head Kvasivka Oleksandr O., Registration Date 27-05-2025 Organization National Cancer Institute popup.description1 The aim of the study is to evaluate the safety and efficacy of transarterial chemoembolization (TACE) in combination with systemic therapy in patients with hepatocellular carcinoma and preserved liver function as a first-line treatment. The primary endpoint is overall survival (OS). Secondary endpoints include progression-free survival (PFS), the conversion rate of unresectable tumors to resectable ones, the frequency and nature of complications related to chemotherapeutic and surgical treatment, and the assessment of patients’ quality of life during and after treatment popup.nrat_date 2025-05-27 Close