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Information × Registration Number 0200U001694, 0197U001155 , R & D reports Title To ascertain the role of invertors in the age-related changes of the heart reaction due to the ischemia and hypoxia popup.stage_title Head Frol'kis V.V., Registration Date 20-03-2000 Organization Institute of Gerontology popup.description2 The aim - to show the possible role of the intracellular regulatory factor (invertor) in age-related changes of the contractile function of isolated heart (IH) and activity of some cardiomyocyte enzymes during prolonged perfusion and postischemic reperfusion. Object - adult and old Wistar rats. Methods: physiological, biochemical. It was shown that sensitivity increased and the endurance of IH to restriction of coronary flow and postischemic reperfusion decreased during ageing. It appeared that the creatine phosphokinase activity in perfusate increased to a greater degree in old rats compared to the adult. The Na,K-ATPase got activated in adult rats and declined in the old. Under prolonged perfusion conditions there synthesizes a factor (invertor) in the heart of adult, unlike old, animals, which reduced the myocardial contractile function regulated and activated the Na,K-ATPase of plasmatic membranes fraction of the cardiomyocytes. Product Description popup.authors popup.nrat_date 2020-04-03 Close