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Information × Registration Number 0200U003648, 0198U005747 , R & D reports Title The investigation of xenobiotics role in the senescence acctlerating mechanisms popup.stage_title Head Lemeshko V.V., Registration Date 03-07-2000 Organization Kharkov National University named after V.N. Karazin popup.description2 The effect of some prooxidant xenobiotics on the antiixidant defense system state in the liver of rats of deferent agt was investigated. The introduction of tetracycline was estadlished tj resuit in essentia cyarges of glutathione-S-transftrance activity only for old rats (as well as greater activation of lipid peroxidation). More essential activation of lipid peroxidation was in old CCl4-treated rats/ It is assumed that the more essential activation of lipid peroxidation under the tetracyccline and CCl4 treatment cjuld be linked to original "failure" of glatation-dependent enzymatic antioxidant system. On drosophyla flys it was shown that the addition phenobarbital in nutritious mixsture in the researced concetration did not essentially influence life time4 of incects, but judging bu some indices of biological age the " phenobarbital" flys were more "young" than control ones. At the same time, the degree of an expressiveness of the observed phenomena essentially depends on a line of lues. Product Description popup.authors popup.nrat_date 2020-04-03 Close