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Information × Registration Number 0202U002361, 0199U000640 , R & D reports Title Influence of ionizing irradiation of neurohumoral regulation of endocrine glands in animals of different age. popup.stage_title Head Gorban' Ye.M., Registration Date 06-03-2002 Organization Institute of Gerontology popup.description2 Design and Methods: adult and old rats. Single X-ray irradiation in sub-lethal and lethal doses, pharmacological selective turning-off of separate components of nervous influences by means of the (- and (-adrenoreactive structures blockers - pirroxan and anaprelin, and M-cholinoreactive structures blocker - atropine. Measurements blood plasma hormones and glucose (fluorometry, radioimmunology and peroxidase assessment), adrenocorticocyte membrane potential and lipid peroxidation in some organs and tissues. The study revealed age-related peculiarities of contribution of (-adrenergic component of nervous regulation of glucocorticoid function adrenals to their early reaction background irradiation. This component did not effect the basal secretion of 11-OCS of the isolated adrenals of intact adult and old rats and provided activation influence in adult rats under conditions of irradiation. The cholinergic component of nervous regulation in the adult rats, unlike old ones, provided the tonic suppressing influence on the basal secretion of glucocorticoids of the isolated adrenals and on blood insuline level, and it remained after single irradiation in sub-lethal dose. Anaprelin administration prior to irradiation caused a decrease in the organism's radioresistance and led to shorting of rat lifespan under condition irradiation in dose 8 Gy. Whereas atropine administration before irradiation promoted increase in the survival of animals under condition irradiation in dose 7 Gy. Product Description popup.authors popup.nrat_date 2020-04-02 Close