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Information × Registration Number 0203U000551, 0100U003767 , R & D reports Title To study the role of immunologic factors in the development of type 1 diabetes mellitus in order to develop pathogenetic therapy schemes. popup.stage_title Head Zak K.P., Man'kovs'kyj M.B., Registration Date 21-02-2003 Organization V.P.Komisarenko Institute of Endoсrinology and Metabolism popup.description2 It has been established in "practically normal" childrenbeing sero-positive for diabetes-associated antibodies (IAA,GADA, IA-2A) the presence of significant changes in acquired and natural immunity indices. Blood level of monocytes was increased in these children, and CD3+, CD4+ and CD56+ immunophenotype lymphocyte content was decreased, with parallel changes in ceell ultrastructure and function. Thus,disturbances of immune mechanisms in human body begin long before appearance of clinical symptoms of type 1 diabetes mellitus. 55635 Product Description popup.authors popup.nrat_date 2020-04-02 Close