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Information × Registration Number 0203U002262, 0101U007612 , R & D reports Title Pharmacological correction of tissues oxygen regime disturbances by antihypoxants popup.stage_title Head Kostenko Vitaliy Alexandrovich, Registration Date 19-02-2003 Organization Ukrainian Medical Stomatological Academy of Ministry of Public Health of Ukraine popup.description2 It was revealed that antihypoxants, introduced in a systemic blood flow (in doses - sodium succinate and mexidol 50 mg/kg, aethonium 30 mg/kg intraperitonealy for 30 min before nephrotomy and through 1; 2; 3; 4; 5; 6 days after operation) and locally (in structure of surgical threads in a dose of 10 mg/kg of mass of an animal), raise energy quotient, phosphorylated activity of mitochondria, limit free radical lipid peroxidation, stimulate reparative processes in ischemic paravulnare tissues after a nephrotomy. On ability to raise energy metabolism antihypoxants, immobilised on the suture material, are distributed thus: mexidol > sodium succinate > aethonium. The given effect of antihypoxants is potented in conditions of moderate rising of an oxygen's regimen of tissues under hyperbaric oxygenation. By method of a morphometry is revealed, that the introduction of antihypoxants in biofil structure accelerates transition wound inflammation on macrophagic-monocytic and fibroblastic stage. The introduction mexidol and aethonium, immobilised on surgical threads, stimulates for 7 day of the postoperative period proliferation of fibroblasts. The restriction of this process by the certain time interval (7-14 days) is warned by develop-ment of superfluous proliferative changes, which conduct to formation of coarse fibrillar cicatrix and stricture of hollow organs. The conclusion is made, that the local introduction of antihypoxants (sodium succi-nate, mexidol and aethonium) in a operational locus (in structure of surgical suture) allows to achieve pharmacological effect in doses considerably smaller (10 mg/kg of mass of an animal), than at systemic introduction. Product Description popup.authors popup.nrat_date 2020-04-02 Close