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Information × Registration Number 0203U002279, 0100U002770 , R & D reports Title To study the significance oxidative-stress component of radiation impact upon the state of the central nervous system popup.stage_title Head Rudnev M.I., Registration Date 23-07-2003 Organization Research Centre for Radiation Medicine popup.description2 Objective: to study the contribution of the oxidative stress mechanisms of the radiation effect upon the central nervous system state for optimization of the unfavorable consequences of this effect correction ways. Object of the studies: oxidative stress mechanisms of the higher nervous activity of the animals (rats) disturbances caused by the exposure to ionizing radiation. Methods of studies: behavioral, polarographic, electrocalorimetric, spectrophotometric, statistical. The effects of the ionizing radiation (0,05 to 7,0 Gy) upon the indices of pro-, antioxidant homeostasis in the tissues of brain and blood, cell membrane state, morphological and functional state of the brain structures, behavior reactions of rats as well as ability some antioxidants (vitamin C, E, beta-carotene, and selenium) used separately and in complexes to diminish exposure effects according to the studies indices have been studied. The largest protective effect was found for beta-carotene as well as for the compositions, which contain it. In the case of the animal exposure at the dose of 0,05 Gy, usage of alfa-tocopherol could cause decline of the animals' behavior reactions indices; this suggest that usage of antioxidant therapy demands certain cautiousness. The indices of the animals behavior reactions could be used for the assessment of the antioxidant preparations effectiveness under the exposure to the agents the effect of which is mediated by the oxidant stress mechanisms. The obtained results suggest the contribution of the oxidant stress component to be leading at least in the dose range of 0,05 Gy to 5,0 Gy. Product Description popup.authors popup.nrat_date 2020-04-02 Close