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Information × Registration Number 0203U008023, 0100U003281 , R & D reports Title Physics, technology and diagnostics of hydroxyapatite -based nanodisperse biomaterials popup.stage_title Head Zyman Z.Z., Registration Date 10-04-2003 Organization Kharkov National University named after V.N.Karazin popup.description2 The object of the research is stoychiometric and non-stoychiometric nanodispersive powder based hydroxiapatite ceramics. The aim of the work is investigation of physical and chemical processes of in vivo stoychiometric and non-stoychiometric hydroxyapatite ceramics dissolubility/ The method of the research — X-ray diffraction analysis, IR-spectroscopy, optica, electron and X-ray microscopy. In vivo investigation of the hydroxyapatite ceramics as blocks and granules dissolubility was carried out by the way of its implantation into the rat's thigh. It was found that dissolving of "dense" and porous samples depends, first of all, on its compound stoychiometry: dense blocks with Ca/P molar ratio equals 1,60 dissolve faster than that with Ca/P =1,67. Second, the dissolving rate increase with a contact effective area increase. When the area is bigas in granules, the dissolving rate of the ceramics on the boundary with a bone more than that of the dense blocks third, it was first found the dissolving processdependence on grain boundary of an implant material cpndition. In the case of non-stoychiometric hydroxyapatite boundary dissolving rate more than the volume one. Forth, due to an increase of effective interfacial area of an organism and an implant allows us to reduce the time of transformation into a live bone. The usage of such hydroxyapatite ceramics in surgical osteoplastyc ought to lead us to effective bone healing. The dissolving rate increases using porous hydroxyapatite ceramics. Considering received in vivo laboratory data, the producing method of hydroxyapatite ceramics with required stoychiometry and transparent porosity elaborated. Product Description popup.authors popup.nrat_date 2020-04-02 Close