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Information × Registration Number 0204U003654, 0198U005834 , R & D reports Title Microbiological and immune effects of glycosides and other bio-active substances popup.stage_title Head Kryvorutchenko Yurij Leonidovych, Registration Date 06-04-2004 Organization S.I.Georgievsky Crimean State Medical University popup.description2 Influence of anomeric MDP derivatives and taurosids (saponins from Hedera taurica Carr.) on HIV-1 and influenza virus expression, adjuvant properties of the MDPs when used with anti-HIV DNA vaccine, ,Candida infection in various groups of patients, and antifungal properties of the taurosids were studied. Taurosid I inability to activate HIV-1 expression was shown. Taurosids Н2 and St-K enhanced HIV-1 expression. They are potentially dangerous to HIV-infected persons. (-butyl МТP deoxycholyl stimulated production of anti-Nef antibodies in mice immunized with DNA plasmid encoded HIV-1 Nef. Taurosid Sx1 was shown to be an activator of resistance of mice to lethal influenza virus infection. Taurosid I and such anomeric MDP derivatives as (- and (- MDP butylglycosids, (- butylglycosid-MDP-dimer, (-butyl МТP deoxycholyl, and (-butyl МТP deoxycholyl had no protective effect in influenza virus infected mice. The presence of bacterial-fungal mixture in the abdomen cavity of aged surgery patients is shown. Yeasts including Candida are predominated. Candida are predominated in the gastric juice of the patients with the gastrointestinal pathology and in the inflammatory focuses of patients with dental problems. The anticandidal effect of Taurosid Sx1 was shown Product Description popup.authors popup.nrat_date 2020-04-02 Close