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Information × Registration Number 0205U000309, 0102U004091 , R & D reports Title Development of methods of rational antimicrobial and immune therapy in complex treatment of generalized periodontitis popup.stage_title Head Kosenko Konstantin Niikolaevich, Registration Date 29-12-2005 Organization Institute of Stomatology popup.description2 248 persons, from them 152 ill generalized parodontit (GP)) are inspected: clinical-X-eay a state estimation of tissues parodont, immunological parameters of a blood, stomatic and crevicular of a liquid, contents citokin in a blood and crevicular of a liquid, biochemical parameters granula of a tissue parodonte of pouchs. The antimicrobial properties klindamicin (" Dalacyna C ") are studied immunodulatori and anti-inflammatory of property of drugs "Biotrit-Denta", "Imudon" and "Lusobakt", concerning a microflora Periodontal of pouchs. For ill GP the associations of microorganisms pariodontal of pouchs with considerable predominance optional both strict anaerobes and yeasty funguses are secured aerobically . Researches in vitro is rotined, that the greatest activity in attitude parodontopatogen of bacterias have the antibiotics amocsiklav, doxycycline, klimadacimin, ciprofloksacin and ofloksacin, concerning yeasty funguses - antimicotici fluconazol and itraconazol. Is established, that with strengthening of a degree GP more expressed violations in a system of local immunodefence of an oral cavity and tissues parodont are determined. The parameters of system immunodefence for ill GP II, II-III of a degree indicate availability of т-cellular immune Deficiency, violation of a function of a humoral link of immunodefence, citokines of a regulation, decrease of a nonspecific resistance of an organism, that testifies to development for an ill secondary immunodeficiencyy and demands differentiated immunocorregires of therapy. The application "Biotrita-Вутеф", "Imudon" and "Lisobact" for ill GP enriches clinical-laboratory parameters of a condition parodont, normalizes a condition of local immunodefence and reduces microbial heriodontal tissues of pouchs, promotes more long-lived and proof remission of disease. The high clinical and bacteriological efficiency climadicina (" Dalacina C ") is established at realization of a system antibiotic therapy for ill with the "aggressive" forms parodontit. Product Description popup.authors popup.nrat_date 2020-04-02 Close