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Information × Registration Number 0206U002121, 0101U007592 , R & D reports Title The Study of role of formaldehyde and nitric oxide (NO) interdependence vetabolism in mechanism of their combined biological action popup.stage_title Head Dmitrenko Mikola Petrovic, Registration Date 27-01-2006 Organization L.I. Medved’s Institute of Ecohygiene and Toxicology popup.description2 It was ascertained thet in conditions of streptozotocin-induced diabetes increased the formaldehyde formation and nitric oxide (NO) stable metanolites founds, It was shown that hydroxilamine cytotoxic action depends from NO partially. Main manifestation of hydroxilamine toxic effect is formation of stable nytrosyl-hemoglobin complex, It was developed the novel metod for determination jf NO role in toxic action of chemicals on mammal's cells in vitro. It was prepared the review about possible exogenic sources of formaldehyde and nitric oxide and accidents, which caused environmental pollution of these cjmpounds and its toxic influrnce on human. It was shown metabolic pfthwais of formaldehyde and NO transformation and various directions of its toxic action5635 Product Description popup.authors popup.nrat_date 2020-04-02 Close