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Information × Registration Number 0206U002430, 0103U001414 , R & D reports Title To Investigate of the chromosome stability and the functional reserve of thyroid system at offspring of parents irradiated in the consequence of Chernobyl accident popup.stage_title Head Pilinskaya Maria Andreevna, Доктор медичних наук Registration Date 08-02-2006 Organization Research Centre for Radiation Medicine popup.description2 Several children groups with and without of thyroid pathology selected with help of endocrinology examination born to parents irradiated by iodine isotopes owing to Chernobyl accident (liquidators and residents of territory with radioactive fallout contamination) have been cytogenetically observed. Chromosome aberrations in peripheral blood lymphocytes with the help of two-termed cultivation (during 48 and 144 hours, that permit to score metaphases mainly of first and fifth mitotic division, accordingly) and conventional chromosome analysis had been studied. Under the standard short-term cultivation observed groups have not significantly differed on the mean-group integrated cytogenetic parameters. Under the long-term cultivation the association between thyroid pathology and the expression of hidden cytogenetic effect in delayed cells' generations had been determined. Thus, in children with chronic thyroiditis significantly increased level of both chromatid (single fragments) and chromosome (abnormal monocentrics) aberrations had been established. The interindividual variability in observed children groups as regard to response of somatic cells' chromosomes to different terms of lymphocytes cultivation had been revealed. It can be assume that delayed chomosome instability expressed under long-term cultivation in children born to irradiated parents may be one of the reasons which promote the realization of thyroid pathology. The data received confirmed the necessity of thyroid and cytogenetic monitoring use among the children of irradiated parents for risk group formation. Product Description popup.authors popup.nrat_date 2020-04-02 Close