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Information × Registration Number 0206U004505, 0103U005436 , R & D reports Title Study on structural basis of interaction of narrow specific enzymes with peptides modified by different heterocyclic systems popup.stage_title Head Kibirev V., Registration Date 28-02-2006 Organization Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine popup.description2 The purification methods of the peptides were developed. The structures of synthesized derivatives were confirmed by NMR and element analysis. By these compounds carried out the inhibitory analysis of human thrombin. The presence of heterocyclic moiety at N-termini of the peptides was shown to result in increase of the peptide affinity to thrombin. These results permit to design the novel and efficient inhibitors of thrombin as potential new remedy.5635 Product Description popup.authors popup.nrat_date 2020-04-02 Close