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Information × Registration Number 0207U002021, 0102U000745 , R & D reports Title Electrophysiological and pharmacological properties of neuronal nicotinic choline receptors with the different subunit composition of sympathetic and parasympathetic ganglia popup.stage_title Head Purnyn Helen, Registration Date 10-01-2007 Organization Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 By use of specific antibodies against fragments (located close to binding site) of nAChRs-alpha-subunits in electrophysiologycal and immunohystochemical experiments was found that autonomic ganglia neurons contain all nAChRs-alpha-subunits used. There are not functional alpha-4 subunits in abdominal ganglia neurons whereas in SCG it could be include in synaptic transmission. It was established that alpha-3 and alpha-7 subunits expressed in SCG neurons are included in different receptors. Functional heterogeneity of autonomic neurons became apparent not only in their electrophysiological and pharmacological properties but also in subunit composition of nACHRs, which could be important factor determining specificity in autonomic pathways. Product Description popup.authors popup.nrat_date 2020-04-02 Close