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Information × Registration Number 0207U002538, 0104U003627 , R & D reports Title Studying of long-term following essential hypertension particularities, structure of target-organs damages, stratification of risk and factors of development of hypertensive complications in Chernobyl disaster survivors and developing preventive pathogenetic measurements popup.stage_title Head Khomazjuk Inna, Registration Date 05-02-2007 Organization Research Centre for Radiation Medicine popup.description2 Objective: 300 clean-up workers after Chernobyl disaster with essential hypertension (EH). Goal: The determining of particular symptoms, exchanges factors, predictors of hypertensive heart desadaptational changes on long term essential hypertension and estimating possibility of left ventricular heart hypertrophy regression in clean-up workers after Chernobyl disaster. Methods: clinical, analysis of irradiation influence as well as others risk factors, daily blood pressure monitoring, electrocardiography, dopplerechocardiography, bicycle ergometry.Results - The particular of symptoms, exchanges factors of hypertensive heart desadaptational changes on long-term essential hypertension in clean-up workers after Chernobyl disaster. The significance of total risk degree is predictor of development and progressing of left ventricular heart hypertrophy (LVH). It was determining in 93,4 % in patients with very high risk. The reliable direct correlation between total risk degree and thickness of left ventricularback wall (r=0,47, P<0,01), interventricular septum (r=0,5, P<0,01), index mass of myocardium were determined. Concentrative LVH was discovered in 57,3 % of patients with very high total risk. In 64,6 % patients of left ventricular heart hypertrophy was estimated the infringement of relaxation. It associated with more high-level risk and shortage night decreasing of arterial blood pressure. The reliable correlation between early and lately left ventricular diastolyc filling and isovolumetric restriction time and thickness and mass of myocardium were determined. In 21 % patients of left ventricular heart hypertrophy the myocardial icshemia episodes and 15,9 % - ventricular extrasystols were discovered by means of Holter electrocardiography. Frequently of myocardial icshemia episodes is maximal of patients with very high total risk and make up 22,9 %. Quantity and length of myocardial icshemia episodes are correlative with thickness and index mass of myocardium. The increasing of total risk degree was associative with total heart rate variability decreasing. The fiscal work capacity was decrease, because arterial blood pressure increase to admiting level. The possibility of left ventricular heart hypertrophy regression by long-term treatment to angiotensin-converting-inhibitors (ACE) (enalapril maleat, perindopril) and thiasid-perticulars diuretic indapamide-retard. It was more extressing when treatment to ACE-inhibitors. When arterial blood pressure decrease target level, the mass of myocardium, quantity and length of myocardial icshemia episodes were reliable increase. The favourable influence to heart rate variability was observing. By results the 41 articles, new method (patent № 177894, 16.10.06), information letter, methodical recommendations, 12 doсlads are prepared. Efficacy: The determining of particular symptoms of hypertensive heart, part of total risk in it development and progressing was increase to early diagnostic possibility of desadaptational changes. The possibility of left ventricular heart hypertrophy regression and functional changes by long-term treatment were optimized by treatment to clean-up workers after Chernobyl disaster wiht essential hypertension. Product Description popup.authors popup.nrat_date 2020-04-02 Close