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Information × Registration Number 0208U000619, 0104U009840 , R & D reports Title Study of apoptosis and caspase activity in myeloblasts varying by differentiation state upon exposure to polyphenols and growth factors popup.stage_title Head Philchenkov Oleksiy Oleksiyovych, Registration Date 05-02-2008 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 The erythroid differentiation of K-562 cells of human chronic myelogenous leukemia induced by natural polyphenols quercetin or resveratrol has been shown to involve several apoptotic mechanisms, namely the increased activation of caspase-3 as well as the increased Bax expression. Therefore, polyphenols may induce the differentiation of blast cells with the involvement of the activation of some apoptosis-associated proteins. NMR spectroscopy allows for detecting the early features of differentiation, in particular the decrease in the methylene to methyl resonances ratio and increase in choline content. The erythroid differentiation of chronic myelogenous leukemia cells induced by DMSO and by quercetin is mediated by the different mechanisms. Product Description popup.authors popup.nrat_date 2020-04-02 Close