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Information × Registration Number 0208U002281, 0103U000073 , R & D reports Title Conformational flexibility and dynamic mechanism of RNA recognition by eukaryotic tyrosyl-tRNA synthetase popup.stage_title Head Kornelyuk Olexander Ivanovych, Registration Date 24-01-2008 Organization Institute of molecular biology & genetics popup.description2 The sientific work was devoted to investigation of dynamic aspects of tyrosyl-tRNA synthetase and its partial modules functioning. Computer modeling of TyrRS spatial structure was conducted and flexible conformation of its interdomain linker was described. During the process of linker dynamics formation of short helices was derived, which, possible, are taking part in regulation of synthetase functioning. The processes was investigated in case of non-catalytic cytokine-like С-module participation. Structure-specific interaction of free TyrRS С-module with tRNAPhe was elucidated and miodelling of this complex was conducted by the macromolecular docking method. RNA-binding surface was found in ОВ-fold domain and КРККК-motif was found in А-subdomain of С-module and contact surface lies in dihydrouridine loop and acceptor stem of tRNA. Product Description popup.authors popup.nrat_date 2020-04-02 Close