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Information × Registration Number 0208U002424, 0105U002468 , R & D reports Title To research of results of individual endoprosthetics of long bone and joint postresection defects in the system of complex treatment of bone tumors popup.stage_title Head Vyrva O.Y., Registration Date 29-01-2008 Organization Sytenko Institute of Spine and Joints Pathology Ukrainian Academy of Medical Sciences popup.description2 The aim of investigation: on the background of theoretic–experimental and practical research tostudy the possibilities of using of individual modular systems for endoprosthesis substitution of bone-joint defects after the removal of malignant tumors with an evaluation of morphological peculiaritics of the formation of bone-ceramic fusion in the case of use of metallic with ceramic coverage and study immunological and biochemical changes in patients with malignant tumors. Object of investigation: tumors of long bones, bone defect, surgical treatment, materials for bone plastics. Biomechanical investigation focused on study of strained-deformed condition of endoprothesis construction and proximal part of femur depending upon the angle of inclination, the length of intramedullar rod, the level of bone resection were carried out. The study of citotoxical influence and biocompatibility of the coverage samples was carried out in vitro with fibroblasts cultivating, biocompatibility and the absence of citotoxical influence of the mentioned samples of coverage was proved. Morphological peculiarities of bone regeneration in the case of use of different metallic, ceramic and combined implants for substitution of bone defects were studies in vivo experiment. In vivo experiment was performed in order to estimate the possibilities of saturation of different ceramic implants with malignant-prevention drugs and kinetics of their way-out into the tissues for the creating treating concentraction in the cirea of tumor location. Clinical approbation of proposed modullar systems, worked out for substitution of postresection bone-joint defects, was performed. Product Description popup.authors popup.nrat_date 2020-04-02 Close