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Information × Registration Number 0209U001523, 0106U004308 , R & D reports Title Study of hydration, conformational properties and interaction of model proteins with physiologically active compounds. popup.stage_title Head Goucha T., Registration Date 06-02-2009 Organization Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine popup.description2 Changes in volume and structure mobility of hydrated serum albumin in the course of thermal fluctuations, conformational transitions, interaction with fatty acids, pharmacological ligands, and inorganic ions have been studied using densitometry, molecular acoustics and numerical modeling methods. It has been revealed that loop-like structures in proteins may possibly initiate and modulate mobility of domains and play essential role in global conformational change of HSA when binding fatty acids. The changes of the protein hydration water structure have been revealed in aqueous sodium chloride solutions indicating the existence of critical phase transition in physiological range of concentrations.5635 Product Description popup.authors popup.nrat_date 2020-04-02 Close