Search academic texts

Information × Registration Number 0209U002338, 0104U000162 , R & D reports Title To study the interaction of 2'-5'-oligoadenylate analogs with phosphodiesterases of cyclic nucleotides and to perform the screening of new anti-inflammatory agents in vitro and in vivo popup.stage_title Head Tkachuk Z.Yu., Dubey I.Ya., Registration Date 09-02-2009 Organization Institute of molecular biology & genetics popup.description2 New methods of chemical synthesis of 2'-5'-oligoadenylates and a series of their analogs were developed. It was shown that the activator of cAMP-phosphodiesterase, calmodulin, could be a target protein for "core" 2-5A which, due to the increase of calmodulin affinity, activate its binding to calcium. Computer modelling provided the structures of complexes. It has been established that natural "core" 2-5A3 and particularly its epoxy-analog stimulate twice the proliferation of bone marrow cells of mice in vitro, and accelerate almost twice the migration of bone marrow stem cells upon syngenic transplantation and demonstrate anti-inflammatory activity. Oligoadenylates were found to have an anti-hypertensive activity. Product Description popup.authors popup.nrat_date 2020-04-02 Close