Search academic texts

Information × Registration Number 0209U008180, 0106U000335 , R & D reports Title To develop a new complex medication with antihelminthic, insecticidal and immunomodulating activities for pets treatment against invasion diseases popup.stage_title Head Keleberda Nikolaj Ivanovich, Registration Date 29-01-2009 Organization National Scientific Center "Institute of Experimental and Clinical Veterinary Medicine" popup.description2 The optimum structure of components of a new complex preparation is picked up, the combination with ivermektine, amixine and auxiliary substances has appeared the best. Developed the medical form is stable, does not cause the general and local inflammatory reaction at hypodermic injections. The studied efficiency of action against endo - and ektoparasites on dogs and cats also is certain a therapeutic dose of a preparation which makes 0,03 sm3/kg of weight of a body. Positive influence of a complex preparation on different links of immune system of animals is established. It is shown that preparation conducting in therapeutic doses, increases contents of circulating immune complexes, raises activity lysozyme and quantity of subpopulations T - and V- limfotsitov. Value LD50 which makes 44,16 sm3/kg of weight of a body at hypodermic introduction which in one thousand times exceeds a therapeutic dose is defined. The destruction of animals at a sharp poisoning, comes owing to an alveolar hypostasis of lungs, in victims pathological changes in a liver are observed. The specifications and technical documentation on a preparation "Ivermeksin" is developed and confirmed in SCIVP. Product Description popup.authors popup.nrat_date 2020-04-02 Close