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Information × Registration Number 0209U010850, 0107U002890 , R & D reports Title The peculiarities of secondary immunodeficites in pathological states of definite origin popup.stage_title Head Nina G. Bychkova, Registration Date 25-12-2009 Organization National O.O. Bogomolets Medical University popup.description2 Report about scientific work: 140 p., 13 pic., 38 tabl., 182 references Object of research: mechanisms of formation of secondary immunodeficiencies at patients with chronic obstructive pulmonary diseases (COPD), atopic dermatitis (AD), children with caries of a teeth both accompanying general pathology and patients with asthma. The aim of research - on the basis of studying of indicators of system and local immunity and level of inflammatory and antiinflammatory interleukins to definite mechanisms of occurrence of secondary immunodeficiencies at a general pathology and to develop their principles immunocorrection. Research methods - clinical, immunological, imunofermental, serological, immunofluoriscence, statistical. 1134 patients, including 611 children with caries of a teeth, 236 patients with asthma, 152 - COPD, 135 - AD and 806 healthy, comparable on age and a sex are observed . It is established that at all observed patients the clinical course of disease is characterised by presence of a secondary immunodeficiency (SID) which degree is caused by weight of a course of disease. The SID is shown by decrease in maintenance CD3 +, CD4 + and CD8 + lymphocytes, concentration of Ig G, A, M, SIgA, decrease of phagocyte activity of neutrophiles, increase of maintenance CD22+, CD25 +, CD95 + and HLA-DR + lymphocytes, high concentration of ІL-1beta , TNF - alfa , ІL-6, and at patients with asthma and COPD - ІL-4; the general IgE and pathogenic CIC. At children caries of a teeth develops against the SID which is characterised by similar changes in the immune status, and local immunodeficiency - decrease in concentration of SIgA and activity of phagocyte cells. The pathogenetic mechanism of development of ophthalmologic complications at patients with AD is infringement of a condition of local immunity of an eye - increase in concentration of IgE and decrease in maintenance of SIgA in tear. Level IgE in tear above 300 MO/ML is a risk factor of development of a cataract. Differential appointment at all patient immune drugs promotes elimination of infringements in system and local immunity. Product Description popup.authors Біденко Н.В. Бичкова Н.Г. Гавриш Т.І. Гаркава К.Г. Добрянський Д.В. Клименко Г.М. Ковальчук Л.В. Мурланова Т.П. Парубець Л.І. Пекур Н.І. Петриченко В.Г. Прохорова М.П. Розумій Н.М. popup.nrat_date 2020-04-02 Close