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Information × Registration Number 0210U000409, 0107U000617 , R & D reports Title To study the functional of gonads, adrenals, kidneys and liver in men with metabolic syndrom and type 2 diabetes mellitus, and etstimate the efficiascy of treatment popup.stage_title Head Luchstsky Yevgen Vasylyovych; Markov Valentyn Vasylyovych, Registration Date 12-02-2010 Organization State Institution "V.P. Komisarenko Institute of Endocrinology and Metabolism оf the Academy of Medical Scienses of Ukraine" popup.description2 Object of research: the internsl organs state in males with metabolic syndrome and a type2 diabetes. A research objective - to investigate a functional condition of endocrine glands, kidneys and liver the males with metabolic syndrome and a type2 diabetes, to develop criteria of early diagnostics of kidney's insufficiency and to estimate efficiency of treatment. Methods of investigation- radionuclide researches of a functional condition of an internal organs, radioimmunological methods of hormone levels definition. The equipment - scintillation tomography gamma-chamber GKS 301 Т СКТБ "Orizon" with low-energy collimator for general purpose, gamma counter Beckman Gamma 5500 In, № 8015006. Results; at patients with DM, metabolic syndrome and visceral obesity was establishes significant decrease in blood of testosterone and degidroepiandrosteron-sulphate concentrations against normal levels as well as gonadotropine hormones levels that testifies the development late onset hypogonadism. After a course testosterone substitution treatment throughout 6 months significant growth of total and free testosterone levels was observed, as well as improvement of the obesity indicators. No significant changes of cortisole concentration in blood and its excretion was observed. Considerable delay of filtration and excretory kidney's functions (despite small duration of a diabetes), delay of arterial inflow, increase in time of venous outflow of blood that can be prognostic indicator of early development and fast progressing diabetic nephropathy. Implementatione rate: articles, reports, the patent. Branch of usage: endocrinology, andrology Product Description popup.authors Безверха Тамара Павлівна Зубкова Галина Аналтоліївна Крохіна Тетяна Іванівна Кузьминська Лариса Антонівна Лучицький Євген Васильович Лучицький Віталій Євгенович Любкіна Марія Миколаївна Марков Валентин Васильович Пона Світлана Михайлівна Рибальченко Вікторія Михайлівна Сологуб Нелля Віталіївна Стаценко Олександр Андрійович popup.nrat_date 2020-04-02 Close