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Information × Registration Number 0210U000914, 0108U003916 , R & D reports Title Novel compounds from natural venoms that selectively interact with neural receptors and ion channels popup.stage_title Head Krishtal O.A., Registration Date 09-04-2010 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 P2X3 purinoreceptors expressed in mammalian sensory neurons play a key role in several processes, including pain perception. From the venom of the Central Asian spider Geolycosa spp., we have isolated a novel peptide, named purotoxin-1 (PT1), which is to our knowledge the first natural molecule exerting powerful and selective inhibitory action on P2X3 receptors. PT1 dramatically slows down the removal of desensitization of these receptors. The peptide demonstrates potent antinociceptive properties in animal models of inflammatory pain. Product Description popup.authors Єгорова О.І. Іванчик Г.О. Бойчук Я.А. Волкова Т.М. Кришталь О.О. Кулик В.Б. Максимюк О.П. Савченко Г.А. Фісюнов О.П. Хмиз В.В. popup.nrat_date 2020-04-02 Close