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Information × Registration Number 0210U000967, 0107U007188 , R & D reports Title Investigation of the mechanism of anti-tumor activity for tocopherol derivative with short side chain to increase effictiveness and to decrease side effect of cytostatic drug сisplatin popup.stage_title Head Donchenko Georhij Victorovich, Registration Date 26-04-2010 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 Administration derivative of Vitamin E on the next day after inoculation of Lewis lung carcinoma cells exhibits antitumor and anti-metastatic activities. Administration of derivative of Vitamin E after visualization primary tumor reliably decreases diameter Lewis lung carcinoma in a dosage of 500 mg/kg. Combined administration of derivative of vitamin E and cisplatin has been shown accurately decrease nephrotoxic effect of cytostatic agent, to increase the survival rate of animals and to improve antitumor and anti-metastastatic action of cisplatin. Product Description popup.authors Бурлака Юлія Борисівна Кліменко Катерина Петрівна Кузьменко Олександр Іванович Лук'янова Наталя Юріївна Паливода Ольга Михайлівна Тодор Ігор Миколайович Трембач Людмила Валентинівна Шпильова Світлана Іванівна popup.nrat_date 2020-04-02 Close