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Information × Registration Number 0210U001133, 0107U000925 , R & D reports Title Treatment of the radiation-associated acute leukemia with use of stem hemopoietic cells procedure of a various origin at survives after Chernobyl Accident in view of molecular-genetic features of pathological process popup.stage_title Head Klymenko Sergey Viktorovich, Registration Date 25-01-2010 Organization State Institution "Research Center for Radiation Medicine of Academy of Medical Sciences of Ukraine" popup.description2 Object: AML, ALL at survives after Chernobyl Accident, inhabitants it is radioactive the polluted territories and persons without the radiating anamnesis.The purpose: To prove use of procedure of transplantation stem hemopoietic cells received from different sources, for treatment of patients by the radioactive-associated leukaemia, survives after Chernobyl Accident, on the basis of studying molecular-genetic features of pathological process and opportunities of processing of a cellular transplant. Methods: morphological, immunological, molecular-genetic, cytogenetic, immunogenetic, cultural, statistical. High efficiency of enrichment magnetic the cleared positive cells with the help of whey cord blood for increase prolypherative activity of a transplant that enables to improve procedure of carrying out autologic transplantation of stem hemopoietic cells for treatment of patients with oncohematological pathology is proved. Perspective it is necessary to count modulation of function of molecules of apoptosis, P-glycoprotein and use ingibitor receptors of tyrozinkynaze, combinations of chemotherapy and stimulators of granulocytopoiesis. Mutations of gene FLT3 do not play an essential role in leukemogenezis at development AML in the survives after Chernobyl Accident. Presence at a HLA-genotype of the person HLA-B*35; HLA-B*51; HLA-Cw *07 and HLA-DRB1*11 it is necessary to count factors of genetic predisposition to AL. Product Description popup.authors Ільєнко І.М. Балан В.В. Дмитренко І.В. Дмитренко О.О. Кучер О.В. Мінченко Ж.М. Мішаріна Ж.А. Прокопенко І.М. Федоренко В.Г. Шляхтиченко Т.Ю. Юрчук Є.А. popup.nrat_date 2020-04-02 Close