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Information × Registration Number 0210U006817, 0106U010880 , R & D reports Title The experimental investigation of psychotropic and neuroprotective activity of exchanging functional state of NMDA receptors drugs popup.stage_title Head Talalayenko Olexandr Mykolayevych, Registration Date 17-12-2010 Organization Donetsk National Medical University after named Gorky popup.description2 It was estabilished increasing of NMDA receptor activity in neuronal membranes of hippocampus, cortex and amygdala in modelling of behavioral depression. The chronic administration of clinicaly active antidepressants diminished neuronal responses evoked by NMDA receptor activation/ The blockers of glycine binding site of NMDA receptors - compounds of TSV serie - manifested antidepressant-like activity in experiments on the rats, which was independent on brain monoamines levels. The chronic administration to rats of antidepressants substantialy decreased neuron injury action of dexamethasone (systemic administration) and excitotoxic action of NMDA (action of amino acid on the brain slices) in experiments on the brain slices/ The neuriprotective action of antidepressants is caused by inhibition of neuronal NMDA receptor activity and increasing of neurotrophins expression which possess tyrosine kinase activity Product Description popup.authors Євдокімов Дмитро володимирович Абрамець Ігор Ігорович Кідін Юрій Валерійович Сидорова Юлія Володимирівна Фролков Віталій Віталійович popup.nrat_date 2020-04-02 Close