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Information × Registration Number 0211U005318, 0106U007002 , R & D reports Title Pathogenesis of inflammatory diseases of the maxillofacial region, improvement of methods of diagnosis and treatmen popup.stage_title Head Lisova Irina Grigorievna, Registration Date 15-04-2011 Organization The Kharkiv Post-graduate Medical Academy popup.description2 The object of study: Chronic inflammation in the salivary glands with lithiasis and without it, mechanisms of immunomorfopatogenesis neyro-psychological and humeral mechanisms of chronic inflammation in the salivary glands; micro flora ducts of salivary glands, the phenomenon of apoptosis in the salivary glands, depending on the virological and microbiological factors. Subject of research: study of complex treatment of patients with chronic sialoadenitis and sialolithiasis against viral persistence mumpus and cytomegalovirus in view of the etiology, pathogenesis and mechanism of development of neuropsychiatric diseases, especially microbial immunopathogenesis and clinical manifestations of disease. The aim of the study. Improved methods of diagnosis and improve treatment of patients with chronic sialoadenitis and sialolithiasis by clarifying the etiology of the disease, microbial-immunologic pathogenesis and taking into account the participation neyro-psychological and humeral links in the pathogenesis of the disease. Methods: analytical, medical history, somatic and local clinical methods of examination of patients with chronic sialoadenitis and sialolithiasis; additional - sialometriya, lyakrometriya, laboratory blood tests: hemogram, immunogram second type, virology; biochemical study of concentration of catecholamines in the tissues of the salivary glands, the study of biopsy material Coll for apoptosis; microbiological research content ducts of salivary glands - quantitative and qualitative composition of aerobic and anaerobic flora and its pathogenicity factors; study of lysozyme, lactoferrin saliva, tissue histology of salivary glands, histochemical studies of tissues of salivary glands; X-ray Diagnosis of salivary glands; ultrasound diagnosis of salivary glands, the definition of the nervous system and the methods of EEG SMEG, studying the psychological state of patients using the test methods for statistical analysis. Scientific novelty: the first time the clinic chronic sialoadenitis depending on neyro-psychological and humeral mechanisms of patients. Clarified features of quantitative and qualitative indicators of the salivary glands, depending on the disorders of the central and peripheral regulations, the morphofunctional state of the salivary glands of patients with chronic sialoadenitis. The relation between the violations neyro-psychological and humeral mechanisms salivary glands in chronic sialoadenitis against viral persistence mumpus and cytomegalovirus and disorders of immune status. First studied the quantity and quality indicators of aerobic and anaerobic microflora of the ducts of salivary glands in patients with various forms of sialoadenitis compared with relatively healthy patients. The interrelation of changes in the indices of lysozyme from saliva flow pattern of inflammation in the salivary glands, the degree of prevalence of disease. The possibility of activation of apoptotic factors in patients with various forms of chronic sialoadenitov taking into account the peculiarities of microbial factors on the background of viral persistence. Confirmed the influence of viral persistence mumpus and cytomegalovirus in the salivary glands on the occurrence of chronic inflammation in them to form concernments. Studied clinical and immunological changes in patients with autoimmune nature sialolithiasis induced persistent viral factor with preferential persistence of CMV, which caused sclerosing structural changes in the salivary glands of stone formation and long-term chronic disease. Defined quantitative and qualitative structural changes in all major salivary glands, regardless of whether concernment in any of them, which emphasized the systemic nature of their defeat by chronic inflammation, the nature of which was due to the kind of persistent viral infection. A complex of therapeutic and preventive measures in patients with chronic sialoadenitami and sialolithiasis based on causal, pathogenetic and symptomatic focus. Practical value: The research allowed us to develop practical recommendations for improving the diagnosis and treatment of patients with chronic sialoadenitis and sialolithiasis taking into account the microbiological and neyro-psychological and humeral mechanisms the pathogenesis of disease. KEY WORDS: chronic sialoadenitis, sclerotic, Sjogren's syndrome, sialolithiasis, mumpus virus, cytomegalovirus, microbial landscape, immune resistance, diagnostics, sialosonografiya, treatment, prevention. Product Description popup.authors Михайленко Ніна Миколаївна Ткач Тетяна Валеріївна Хасанова Галина Біктімірівна Ярославська Юлія Юріївна popup.nrat_date 2020-04-02 Close