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0211U005783,
0107U008259
,
Variable biotechnology usage for the correction of morphofunctional state of myocardium in experimental cardiomyopathy condition.
Zaporozhan Valeriy,
14-12-2011
Odessa State Medical Universitu
At the organism, cellular and tissue levels the changes that occur in the myocardium of experimental male animals under conditions of experimentally induced pathology- dilated cardiomyopathy, have been invented. Different methods of cell material obtaining have been worked out: from bone marrow and adipose anymals' tissues. Protocols of differentiation in mesenchymal cells into cardiomyogenic direction using different substrate are created. It was shown that the best feeder layer was collagen; cell culture, which it was grown on agar substrate, showed weaker ability to attach and development than other cells. It was theoretically confirmed and experimentally proved the possibility of mesenchymal progenitor cells to restore structural integrity and functional capacity of myocardium. In comparison with animals without correction after injection of the cell mixture the density of abnormal cardiomyocytes has decreased more than 4-fold and almost in 3-fold density has increased of normal ones in the myocardium of these animals. The general condition of animals after correction was improved: motor activity increased, the animals began to take care of their skin. Thus, according to the data of positive influence of the correction method for myocardial regeneration that was chosen it can be considered the effectiveness of the method that was used and the great interest of it for further development.
Запорожан Валерій Миколайович
Кулєшова Олена Анатоліївна
Перепелюк Миколай Миколайович
Холодкова Олена Леонідівна
2020-04-02
Updated: 2025-12-18
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