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Information × Registration Number 0211U005876, 0110U005758 , R & D reports Title Cationic antimicrobial peptides: expression patterns in melanoma cells in vitro and in vivo popup.stage_title Head Роgrebnoy Petro Vasylievich, Registration Date 13-12-2011 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 The profile of expression of genes coding for human beta-defensins-1-4 (hBD-1-4) and antimicrobial peptide cathelicidine (CAMP) has been studied in 3 stable human melanoma cell lines - МelZ (moderately differentiated melanoma), Мel Mtp and Мel Is (low differentiated melanoma). It has been shown that in all 3 cell lines in the absence of inducers expression of hBD-1,-2, and -4 is not detected; Mtp cells do not express САМР genes in contrary to Mel Is and Mel Z cells. The presense of hBD-3 mRNA was detected in Mtp cells, but not in Mel Is or Mel Z cells. Metabolite 1,25-(ОН)2Д3 is a positive regulator of hBD-2 gene in all studied cell lines. Action of 10-1000 nМ rec-hBD-2 resulted in significant suppression of cultured melanoma cells realized via activation of retinoblastoma protein pRB and inhibition of expression of proteins p16ink4A, CDK4, cycline D1 and р53 Product Description popup.authors Глушко Наталія Віталіївна Журавель Олена Валентинівна Солдаткіна Марія Олександрівна popup.nrat_date 2020-04-02 Close