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Information × Registration Number 0211U009499, 0111U007110 , R & D reports Title Regioselective synthesis of drug-like molecules - derivatives of 4,7-dihydropyrazolo[1,5-a]pyrimidines. popup.stage_title Head Kolosov Maksim, Registration Date 26-12-2011 Organization Kharkov National University named after V.N. Karazin popup.description2 The object of investigation is target synthesis of 3?functionalized derivatives of 2-aryl-4,7-dihydropirazolo[1,5-a]pyrimidine, namely, the synthesis of 3-cyano- and 3-thioamido-2-aryl-4,7-dihydropirazolo[1,5-a]pyrimidine, based on which can be obtained a wide range of derivatives. The aim of the work is to work up a common synthetic route to the derivatives of 2-aryl-4,7-dihydropirazolo[1,5-a]pyrimidine, containing substituent at the position 3, capable for further functionalization or elimination. Methods of investigation - organic synthesis, 1H NMR-, mass-spectrometry, TLC. A convenient approach to target synthesis of 3-functionalized derivatives of 2-aryl-4,7-dihydropirazolo[1,5-a]pyrimidines by three component condensation of 3-aryl-4-cyano-3(5)-aminopirazoles, aldehydes and dicarbonyl components, was worked up. The pathways of modifying of cyano-group were considered. The field of application - organic chemistry. Product Description popup.authors Білобородов Д. Колосов М. Кулік О. popup.nrat_date 2020-04-02 Close