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0212U000194,
0108U009882
,
The involvement of inflammatory and regulatory factors of natural immunity in the regulation of resistance in chronic cytomegalovirus and candidal infection
Prilutsky Aleksandr Sergeevich,
23-01-2012
M. Gorky Donetsk National Medical University
We examined 30 pregnant women and 30 HIV-infected patients, and 283 children with subfebrile (n = 122) and timomegaly (n = 161), 70 women with candidiasis. We investigated the specific antibodies, cytokine levels and inflammation markers. Methods: ELISA and PCR. A high frequency of cytomegalovirus infection among registered healthy individuals, pregnant women and patients with timomegaliey, subfebrilitet, HIV-infected patients.When analyzing the frequency of occurrence of different combinations of activation markers of infection indicated that 22.1 4.7% of cases to confirm active infection only with the help define specific IgA, IgM, IgG antibodies nizkoavidnyh,and in the remaining cases, an active infection with the same frequency or confirmed the presence of only the virus genome in blood,or in combination with antibodies.Found increased synthesis of CRP in the active CMVI. Given the important role of zinc in the processes of immune regulation, identified by reduced its concentration in the serum of patients with positive markers of replication of CMV, apparently, is one of the reasons for failure of immune response to the virus.
Лєсніченко Денис Олександрович
Майлян Едуард Апетнакович
Резніченко Наталя Анатоліївна
Ширшова Вікторія Миколаївна
2020-04-02
Updated: 2025-12-08
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