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Information × Registration Number 0212U001190, 0109U001236 , R & D reports Title To improve diagnostics and treatment sick of an allergic rhinitis with different sensitisation popup.stage_title Head Zabolotnyy Dmitro I., Registration Date 24-01-2012 Organization Kiyv Research Institute of Otolaryngology named after prof. O.S.Kolomiychenko popup.description2 Determined the frequency of sensitization to various combinations of residential and pollen allergens in patients with allergic rhinitis according to age and gender. The clinical features of the course of allergic rhinitis according to the type of sensitization. Changes of subpopulation composition of immunocompetent cells and concentrations of the major cytokines in the blood of patients, depending on the type of sensitization and the dynamics of oral and injectable SIT household and pollen allergens. The presence of a significant change in the system of pro-inflammatory cytokines in patients with allergic rhinitis with concomitant sensitization to pollen allergens and household compared with a year-round and seasonal allergic rhinitis with monovalent sensitization. Ingenious schemes of treatment of patients with concomitant allergic rhinitis, sensitization to pollen allergens and household method of allergen-specific immunotherapy using intravenous or oral forms of allergens by means of which achieved a significant reduction of clinical symptoms of allergic rhinitis with concomitant sensitization of more than 90% of patients and significant reduction in the level of sensitization to causative allergens. For significant improvement in the main progressive studied parameters (lower level IgE, reduction in size of papules during skin prick test and normalization of the function of ciliated epithelium, restoration of nasal breathing, feeling better patients) justified the optimal duration of immunotherapy on established lines, which is 3 years. Immunological studies have shown that oral SIT with established lines in patients with allergic rhinitis with concomitant sensitization to pollen allergens and household is more effective and leads to normalization of reagin (IgE and IgG4), as well as all the pro-inflammatory cytokines. Confirmed the high safety of parenteral and oral allergen-specific immunotherapy. Product Description popup.authors Верьовка Сергій Вікторович Волосевич Лариса Іванівна Гайдук Владислав Іванович Гогунська Інна Володимирівна Забродська Людмила Валеріївна Зарицька Ірина Станіславівна Маляренко Тетяна Володимирівна Тимченко Марина Дмитрівна Холоденко Тетяна Юріївна popup.nrat_date 2020-04-02 Close