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Information × Registration Number 0212U001716, 0109U003987 , R & D reports Title The Search of biological active substances in the line of 1,2,4-triazol and their galogen-, amino- and thioderivatives for synthesis of new original medicines compounds popup.stage_title Head Panasenko Oleksandr Ivanovich, Registration Date 29-02-2012 Organization Zaporozhye State Medical University popup.description2 The main aim of the dessertation is the synthesis of new high performance and low toxic compounds whith potential antimicrobial, diuretic, analeptic, antivirus, anticonvulsion activities among the 5-(furan-2-il)-4R-1,2,4-triazole-3-thions, and their S-derivatives, establishing of regularity of ties between chemical structure and biological effect, recommending before clinical actions of new effective drugs. New effective synthesis methods of 5-(furan-2-il)-4R-1,2,4-triazole-3-thions and their S-derivatives. The structure of synthesied compounds had been contirmed by ultimate analysis, methods of ultraviolet, IR- spectroscopy, PMR-spectrometry analysis and counter synthesis. 2- 5-(furan-2-il)-2H-1,2,4-triazols-3-ilthio acetas acids piperidining salt, which has express antivirus effect and 2- 5-(furan-2-il)-4-phenyl-4H-1,2,4-triazols-3-ilthio -1-(4-clorphenylethanons), which has anticonvulsion activities are worked out for the presenting to the pharmacological centre of Ukrainian Health Ministry. Product Description popup.authors Іваненко Тарас Васильович Гоцуля Андрій Сергійович Каплаушенко Андрій Григорович Книш Євгеній Григорович Парченко Володимир Володимирович Сафонов Андрій Андрійович Щербина Роман Олександрович popup.nrat_date 2020-04-02 Close