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Information × Registration Number 0212U004078, 0109U007838 , R & D reports Title Nanosized systems for delivering anticancer substances based on novel luminescent and X-ray detectable oligoelectrolytes popup.stage_title Head Stoika Rostyslav Stepanovych, Registration Date 26-01-2012 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 New perspective ways are offered for the synthesis of luminescent and magnetic nanocomposites and also studied possibilities for their usage as novel drug delivery systems in vitro and in vivo. These ways are based on a synthesis and application of new type of functional oligoperoxides, their co-ordinated complexes with cations of transitional (inclusive with rare-earth) metals for the controlled synthesis of sectional, comb-like oligoelectrolites or their nanogels, and also for the matrix synthesis of functional polymers and polymer-mineral nanoparticles. The created nanosized systems were tested for delivery of anticancer drugs both in vitro and in vivo. It was found that the use of oligomeric carrier VA-MANG-MP and VEP-GMA for delivery of anticancer druig doxorubicin to tumorcells was able to reduce effective concentration of this very toxic drug in 10 times. A similar effect was also observed on also in vivo studies on murine NK/Ly lymphoma. Lectin-conjugated nanoparticles which can be vizualived by physical methods were investigated as biomarkers for visualization of pathological cells. Therefore such carriers are perspective for development of new ways in chemotherapeutic treatment of cancer patients.The achieved results were published in 2 article and 20 conference thesis Product Description popup.authors Білий Ростислав Олександрович Бойко Наталія Миколаївна Кіт Юрій Ярославович Панчук Ростислав Русланович popup.nrat_date 2020-04-02 Close