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Information × Registration Number 0212U004405, 0110U002250 , R & D reports Title Development of main criterion for application of silica sorbents with biomimmetic dye-ligands for recieving diagnostic and terapeutic protein preparation popup.stage_title Head Danysh Taras Vasylovych, Registration Date 09-02-2012 Organization LVIV RESEARCH INSTITUTE OF BLOOD PATHOLOGY AND TRANSFUSIONAL MEDICINE popup.description2 Objects of research: fraction of blood plasma by Cohn, affine silica sorbents, proteinase preparations from plasma. Objective: To create a set of bio-targeting sorbents based on macroporous silica matrix, suitable for rapid analysis and purification of proteins with diverse biological material. The purpose of the annual round: explore the use of algorithms derived sorbents for the analysis and separation of protein factors of biological fluids. Methods: chemical synthesis, fractionation, affine and gel-permeable chromatography, centrifugation, PAAG-electrophoresis et al. As a result of work obtained by the following scientific and practical results: a comparative study of the properties of silica sorbents and sorbent-based matrix Toyopearl, determined from the conditions of application of sorbents for the analysis and separation of protein factors of biological fluids studied esterase activity of coagulation factors in plasma subfractions using chromogenic specific substrates, conducted a comparative analysis of protein fractions of biological fluids obtained after dye-ligand chromatography. Degree of implementation: laboratory regulations applying biomimetic sorbents in proteome analysis, reports on international scientific forums and publications in scientific literature, RK technology. Scope: blood transfusion stations, chemical and pharmaceutical companies, research organizations. Efficiency: the combination of chromatography with other bio-targeting methods will facilitate research and proteomic metabolome. Biomimetic sorbents can be used in technology selection and purification of protein factors, including recombinant. Product Description popup.authors Вороняк М.І. Вус М.М. Даниш Т.В. Дульцева Н.А. Дяків Х.І. Мадич С.Є. Орлова Л.В. popup.nrat_date 2020-04-02 Close