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Information × Registration Number 0212U004742, 0110U006130 , R & D reports Title Nanoconjugates of novel antitumor agents based on the specific ligands of quadruplex DNA - inhibitors of telomerase. popup.stage_title Head Dubey Igor, Доктор хімічних наук Registration Date 25-01-2012 Organization Institute of Molecular Biology and Genetics popup.description2 New derivatives of porphyrins, cyanines and acridones were prepared. Compounds were found that inhibit telomerase in vitro in micromolar concentrations. The interaction of ligands with G-octets was studied by quantum-chemical methods. The interaction of porphyrins with duplex and quadruplex DNA was investigated using spectral methods. Work on the modification of dextran, hyaluronic acid and polyethyleneglycol has been continued. Product Description popup.authors Ільченко Микола Миколайович Авдєєв Станіслав Сергійович Арешков Павло Олександрович Дубей Лариса Василівна Криворотенко Дмитро Валентинович Кузів Ярослав Богданович Негруцька Валентина Володимирівна popup.nrat_date 2020-04-02 Close