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Information × Registration Number 0213U000134, 0110U005644 , R & D reports Title Technology development and production of new nanosized broad-spectrum bactericide materials and conjugated nanobiotechnological antitumoral hypotoxical preparations based on the silver, gold, copper nanoparticles in the colloids and suspensions of dispersive silica. popup.stage_title Head Eremenko Anna Mikhaylovna, д.х.н. Registration Date 17-01-2013 Organization Institute of Surface Chemistry of the National Academy of Sciences of Ukraine popup.description2 During the reporting period, the methods of encapsulating of gold (Au), silver (Ag) and copper (Cu) nanoparticles (NPs) by the amino acid tryptophan (Trp) in solution and on the surface of dispersed silica (SiO2), as well as stabilizing the copper nanoparticles which are inclined to oxidation by combination with iodine ions, polymer or colloidal silica have been developed. The Giant Raman Scattering of Trp molecules in the system Trp/Au/SiO2 and Trp/Cu/SiO2 has been found. The mechanism of action of silver NP on the cell microbe C. albicans using a laser scanning confocal microscope using a fluorescent label has been investigated. The main indicators of high antimicrobial activity of metal NPs for a long time are the small size of NPs and clearly defined concentration of selected stabilizers. It is shown that the first step to destroy microorganisms is destruction of cell membranes and penetration of the silver NPs inside the microbe. These results make it possible to recommend the use of silver NPs as an environmentally safe means in medicine, biology, food industry (packaging materials, packaging) and other applications that require the presence of antimicrobial properties. Preliminary evaluation of protective properties and cytotoxicity of Au (Ag) systems covered with Trp molecules in relation to normal and malignantly transformed cells based on the parameters of growth and inhibition of metastasis of Lewis' carcinoma and life of laboratory animals . Product Description popup.authors Єременко Ганна Михайлівна Корчак Галина Іванівна Міхієнкова Анна Іванівна Муха Юлія Петрівна Петрик Ірина Сергіївна Смірнова Наталія Петрівна Шмараков Ігор Олександрович popup.nrat_date 2020-04-02 Close