Search academic texts

Information × Registration Number 0213U000138, 0112U001768 , R & D reports Title Biological activity of oxamino-derivatives acyclic and heterocyclic condensered systems to influenza viruses, herpes viruses, clinical isolate of bacteria and yeasts of genus Candida. popup.stage_title Head Shirobokov Vladimir Pavlovich, Registration Date 17-01-2013 Organization National Medical University by Bogomolets popup.description2 Object of research - the spectrum of biological activity for the first time synthesized compounds derivatives of acyclic and heterocyclic condensed systems of oxiamins; viruses, test-strains and clinical isolates of bacteria and fungi of genus Candida. The aim of the work is to determine the biological activity of the studied compounds in relation to the influenza virus, herpesvirus, clinical isolates of bacteria and fungi of genus Candida. The aim of the work is to determine the correlation between chemical composition of compounds and their antimicrobial action, select the perspective substances for preclinical and clinical investigations with the subsequent possible their clinical use. In the work we used microbiological and virological methods of research. It was determined that MIC of the compounds for clinical isolates of microorganisms, mainly, was in corelation with the values of MIC for museum strains of bacteria and fungi of the genus Candida; the most antibacterial and antimycotic activity showed the substance with adamantan components; antiviral action had substances with acyclic components in alcoxi group; substances with a cyclic compounds in alcoxi group have shown no antimicrobial action. Product Description popup.authors Бобир Віталій Васильович Волощук Олена Михайлівна Короткий Юрій Васильович Можаровська Раїса Данилівна Понятовський Вадим Анатолійович Рибалко Світлана Леонтієвна Степанова Тамара Федорівна Широбоков Володимир Павлович popup.nrat_date 2020-04-02 Close