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Information × Registration Number 0213U000408, 0109U008731 , R & D reports Title To develop and introduce modern technologies of diagnostics, treatment and preventive maintenance of a good-quality pathology of genitals of women popup.stage_title Head Nosenko Olena Mikolaivna, Registration Date 06-02-2013 Organization Donetsk National Medical University after named Gorky popup.description2 OBJECT: womenfolks in childbearing age and in perimenopausal age combined with gynecological pathology - sterility and hysteromyoma. OBJECTS: to determine interrelation between menstrual disfunction in patients with hysteromyoma and undifferentiated dysplasia of connective tissue (UDCT); to detect most important markers for UDCT, its frequency in womenfolks with menstrual function disturbances and with non-malignant pathology of genitals. To optimize methods of surgical treatment of non-malignant pathology of uterus and uterine appendages. To improve methods of organoretentive operation in reproductive organs. RESULTS: the interdependence of menstrual disfunction and UDCT have been determined in patients with hysteromyoma. The frequency of UDST has been researched in womenfolks with menstrual function disturbances and with non-malignant pathology of genitals. The menstrual cycle disturbances have been ranged in 61,4-84,5 % of womenfolks with hysteromyoma and have been diagnosed in 25,2-54,4 % of women from general population in time of preventive medical control. The correlation of angiogenic growth factors of apoptosis has been revealed for indices of myomatous node vascularization in childbearing age women. The methods of surgical treatment of non-malignant pathology of uterus and uterine appendages have been improved. It was demonstrate that selection method of conservative myomectomy is laparoscopy, which renders most sparing therapy and which decreases risk of commissural extension in the sequel. NOVELTY: for the first time it has been detected that womenfolks with nonatypical endometrium hyperplasia and infertility have been had in endometrium dysfunction of immunological reactivity with CD56+НК-cells reduction against the background CD16+НК-cells advanced endometrium infiltration. It has been deeply reduced pregnancy probability and has been required specific immunomodulatory therapy combined with complex treatment of hyperplasia. Product Description popup.authors Бабенко Оксана Михайлівна Бобрик Наталія Миколаївна Васильєва Людмила Леонидівна Гайдадим Віра Вікторівна Дорошенко Венера Енберівна Железная Ганна Олександрівна Жихарський Роман Володимирович Корнієнко Світлана Михайлівна Носенко Олена Миколаївна Попова Марина Володимирівна Фаїд Арар Фаннуш Рамі Чайка Кирило Володимирович popup.nrat_date 2020-04-02 Close