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Information × Registration Number 0213U000731, 0110U003407 , R & D reports Title Clinical and experimental substantiation of application preparations, stabilize of protein and membranous components of the tissues at the various pathological state of anterior and posterior part of eye popup.stage_title Head Leus Nikolai F., Registration Date 13-03-2013 Organization The Filatov Research Institute of Diseases and Tissue Therapy popup.description2 The object of research - the activity of antioxidant enzymes and the levels of glycine in the tissues of diabetic cataract in allergic uveitis and cataract, diabetes ditizone, proteolytic processes during retinal degeneration. Purpose - the rationale for the use of drugs that stabilize the protein and membrane components of tissues in various pathological conditions the anterior and posterior parts of the eye. Research methods and apparatus - biochemical, clinical, statistical analysis, spectrophotometer SF-26, spectrophotometer Spekol 210, pH meter "Seven Easy", torsion balance BT-500, thermostat MIM, centrifuge "MPW-310". Results and novelty. Overall analysis of the results noted that the degree of pathological changes in the retina of rabbits with light effects in the use of drugs of systemic enzyme therapy, especially if the drug "Phlogenzym", lower. It was also a warning fall proteolytic capacity and binding of inhibitors of proteolysis in the retina of rabbits, indicating a more pronounced protective effect on the retina (compared to the drug "Wobenzym") modeling of degenerative process. Revealed the stimulating effect of the drug "Phlogenzym" on functional status of the visual analyzer and proteolytic potential of the organism of patients age-related macular degeneration (increased total proteolytic activity by 33.3% and decrease antiproteolytic activity by 20.8% (p <0.05) compared with control group after treatment). In the simulation model ditizone diabetes revealed severely impaired morphological pattern and antioxidant status of the retina retina of rabbits. Revealed a sharper degree of antioxidant capacity in the fall of the lens of cataract patients with diabetes (superoxidedismutase - by 25.6%, catalase - by 17.0%, and glutathione peroxidase - 32.1%) and the reduction of glycine (31.2%) compared with those of patients with age-related cataracts. The possibility of recovery of impaired thiol status in modeling cataract against allergic uveitis and application ethylmethylhydroxypyridine succinate (mexidol). Complex therapy mexidol has a marked effect on correcting violations of thiol metabolism in the blood and stabilize the performance of the relative scattering of light inside the eye in the long-term period of follow-up of patients with early cataracts, chronic anterior uveitis. In the study of changes in the clinical forms of tuberculosis eye on the background of tuberculous lesions of the body with concomitant diseases (gipotrofic patients with diabetes) had an imbalance of cellular and humoral immunity, and a significant decrease in the immunoregulatory index, indicating a severe clinical course of infection, worsening of the clinical process through recurrence of the disease. There was a positive trend in the immunological parameters in patients with ocular tuberculosis on the background of tuberculous lesions of the body with concomitant diseases under the influence of immunological treatment. On the established model of fungal keratitis moderate to severe confirmed the therapeutic efficacy of a new treatment method - fotodinamic therapy using methylene blue and exposure to low-energy laser with a wavelength of 630-670 nm Product Description popup.authors Байдан Олена Іванівна Борисова Марія Ільїнічна Вашах Зіяд Махмуд Гладуш Тетяна Іванівна Дорохова Олександра Едуардівна Драгомирецкая Олена Іванівна Ендржеевська Тетяна Вячеславівна Зборовська Олександра Володимірівна Коломийчук Сергій Григорович Коновалова Наталя Валерівна Кучеренко Світлана Михайлівна Леус Микола Федорович Нарицина Наталя Ільїнічна Олейник Тетяна Володимірівна Савко Валентин Валентинович Савко Валентин Владиславович Серебрина Тетяна Михайлівна Халіфі Амані Бент Аяши Черепенко Ганна Анатоліївна Шишкина Тетяна Іванівна popup.nrat_date 2020-04-02 Close