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Information × Registration Number 0213U002372, 0111U005968 , R & D reports Title Development of technology for the drug to treat diseases of the skeletal system and to organize its industrial production. popup.stage_title Head Komisarenko Serhiy V., Доктор біологічних наук Registration Date 25-01-2013 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 It was developed technology for complex preparation "Mebivid" (complex of vitamin D3, calcium and bisphosphonate - metylenbisfosphonic acid) with the greatest therapeutic bioequivalence. Regulations, analytical regulatory documentation for a product has been elaborated and issued. It was found that the storage life of the preparation and 25OHD3 bioavailability for the organism is strongly dependent on the presence of finished form of cholecalciferol in the preparation. Efficacy of "Mebivid" treatment in normalization of D-vitamin status, mineral metabolism, and structural-functional state of bone tissue impaired in nutritional osteoporosis has been demonstrated. Toxicological studies revealed that no alterations of basic integral parameters, hemodynamic changes, inflammatory reactions and degenerative disorders occurred in the organs of experimental animals. Product Description popup.authors Апуховська Л.І. Безусяк А.І. Василевська В.Н. Великий М.М. Лотоцька О.Ю. Макарова О.О. Халімон Т.В. Хоменко А.В. Шиманський І.О. popup.nrat_date 2020-04-02 Close