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Information × Registration Number 0213U002451, 0110U001293 , R & D reports Title Derivatives of carcass amines and acids in the synthesis of new alicyclic and heterocyclic compounds. Experimental and theoretical investigation popup.stage_title Head Okovytyy Sergiy Ivanovich, Registration Date 29-01-2013 Organization Dniepropetrovsk national university popup.description2 Object of study - frame imides, amines, amino alcohols and their derivatives, nitrogen containing derivatives of endic anhydride. Purpose - to develop of new methods for the synthesis of amino alcohols and skeletal frame acids, methods of transformation of the past into new heterocyclic compounds, the establishment of the laws of the processes in heterocyclization reactions of these compounds by means of spectral and quantum chemical methods. Research methods - spectral (IR spectroscopy, 1H and 13C NMR, COSY, NOESY, HMQC, HMBC methods, mass spectrometry), quantum-chemical methods, X-ray analysis. A convenient preparative methods for the synthesis of new amino alcohols and amines involving several norbornene, norbornane and adamantane and glycidyl ether, to implement a comprehensive spectral investigation of the products, established the stereochemical features of their structure. Methods for functionalization of aminoalcohols on alternative reaction centers. A comprehensive study of a number of reduction reactions epoksiimidiv norbornane borogidridamy complex metals. Using the data of quantum-chemical calculations the regularities of reaction mechanisms frame amines conformationally mobile epoxy glycidyl ester derivatives. The influence of the nature of the frame (bicyclic, tricyclic, saturated, unsaturated, etc.), its distance from the reaction center and stereochemical features of sulfonamides on the conditions and the possibility of introducing a fragment glitsidilu. The biological activity (analgesic, anticonvulsant, sedative, antihypoxia, anti) and the acute toxicity of some of the synthesized compounds, in some cases, the dependence of the strength of the biological effects of the structural and electronic factors. The results obtained can be used to create new drugs and polymer composites with valuable properties, as well as to solve some theoretical and experimental organic chemistry. Applications: synthetic organic chemistry, pharmaceutical chemistry and agriculture. Product Description popup.authors Гапонов Олександр Олексійович Пальчиков Віталій Олександрович popup.nrat_date 2020-04-02 Close